منابع مشابه
Clinical mapping of conjunctival melanomas.
AIM To develop a system for clinically mapping conjunctival melanomas, taking into account the tumour's stage of development, location and extent. METHODS Baseline clinical features of 40 patients with conjunctival melanoma, first treated at our centre between 1993 and 2006, were studied. Maps showing sectorial location and circumferential spread in all areas of conjunctiva were digitally gen...
متن کاملSurgical management of conjunctival melanomas.
I t has been proposed that ocular surface melanomas should be treated by simple local excision and cryotherapy to the conjunctival borders. Based on what is known of the biology of both cutaneous and mucosal melanomas, however, we consider it unlikely that such a technique, without deep scleral clearance, will reliably eliminate ocular surface melanomas. Indeed, the documented behavior of melan...
متن کاملImmunohistochemical studies of conjunctival nevi and melanomas.
OBJECTIVE To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations. DESIGN Retrospective immunohistopathologic study. METHODS Paraffin-embedded tissue sections from 20 conjunctival nevi and 15 invasive melanomas were immunoreacted with antibodies against cellular antigens S-100 protein, MART-1, HMB-45, CD-45, and Ki...
متن کاملConjunctival melanomas harbor BRAF and NRAS mutations--response.
In our recently published study (1), we describe genetic similarities between conjunctival and cutaneousmelanoma and propose that the treatment rationale for patients with metastasized conjunctival melanoma should be adapted to that for metastasized cutaneous melanoma. Weber and colleagues (2) responded to this, reporting that a BRAF V600E–mutant metastasized conjunctival melanoma patient treat...
متن کاملConjunctival melanomas harbor BRAF and NRAS mutations--Letter.
tions and similarities in chromosomal gains and losses (1). Specifically, 27% of 78 primary or locally recurrent conjunctival melanoma samples harbored a BRAF V600E mutation. Another study also demonstrated BRAF V600E mutations in 58% of conjunctival melanomas (primary and metastatic) (2). The incidence of this mutation approximates that reported in cutaneous melanoma (3). Now that two phase II...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2002
ISSN: 0003-9950
DOI: 10.1001/archopht.120.12.1625